Roger J Davis Selected Research

Protein Kinases (Protein Kinase)

1/2021	JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.
4/2016	Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.
1/2016	Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development.
6/2014	Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.
8/2013	Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity.
11/2011	The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo.
5/2011	p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis.
2/2008	Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.
5/2005	Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.

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Roger J Davis Research Topics

Disease

19	Neoplasms (Cancer) 06/2020 - 09/2002
17	Obesity 12/2021 - 08/2004
16	Insulin Resistance 12/2021 - 12/2008
13	Inflammation (Inflammations) 12/2021 - 06/2005
8	Carcinogenesis 06/2020 - 08/2003
8	Ischemia 01/2016 - 01/2003
6	Fibrosis (Cirrhosis) 12/2021 - 11/2007
5	Prostatic Neoplasms (Prostate Cancer) 08/2016 - 07/2012
5	Adenocarcinoma 08/2016 - 07/2012
5	Necrosis 04/2016 - 12/2004
5	Hypoxia (Hypoxemia) 10/2013 - 11/2004
4	Type 2 Diabetes Mellitus (MODY) 09/2015 - 05/2005
4	Carcinoma (Carcinomatosis) 10/2012 - 10/2003
4	Infarction (Infarctions) 06/2007 - 08/2003
3	Cysts 01/2022 - 01/2021
3	Cholangiocarcinoma 12/2021 - 01/2020
3	Infections 01/2019 - 06/2002
3	Liver Diseases (Liver Disease) 11/2017 - 01/2013
3	Hepatocellular Carcinoma (Hepatoma) 11/2017 - 03/2011
3	Hepatitis 04/2016 - 01/2009
3	Lung Injury 07/2003 - 01/2003
2	Liver Cirrhosis (Hepatic Cirrhosis) 12/2021 - 07/2014
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 03/2016
2	Heart Failure 01/2021 - 04/2011
2	Reperfusion Injury 01/2021 - 06/2003
2	Sarcoma (Soft Tissue Sarcoma) 01/2018 - 03/2009
2	Melanoma (Melanoma, Malignant) 01/2017 - 12/2010
2	Acute Liver Failure (Fulminant Hepatic Failure) 04/2016 - 07/2007
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 09/2015 - 05/2005
2	Alzheimer Disease (Alzheimer's Disease) 08/2015 - 11/2011
2	Multiple Sclerosis 09/2011 - 09/2006
2	Brain Injuries (Brain Injury) 10/2010 - 11/2004
2	Lyme Disease (Disease, Lyme) 10/2007 - 06/2002
2	Cardiomegaly (Heart Hypertrophy) 05/2006 - 06/2002
2	Arthritis (Polyarthritis) 04/2006 - 06/2002
2	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2004 - 01/2004
1	Autosomal Dominant Polycystic Kidney (ADPKD) 01/2022
1	Chronic Renal Insufficiency 12/2021
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 12/2021
1	Hypotension (Low Blood Pressure) 01/2021
1	Left Ventricular Dysfunction 01/2021
1	Hypertension (High Blood Pressure) 01/2021
1	Hyperlipidemias (Hyperlipidemia) 01/2021
1	Hyperglycemia 01/2021

Drug/Important Bio-Agent (IBA)

35	Phosphotransferases (Kinase)IBA 12/2021 - 06/2002
20	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2003
17	CytokinesIBA 12/2021 - 06/2002
12	p38 Mitogen-Activated Protein KinasesIBA 01/2016 - 06/2002
9	Protein Kinases (Protein Kinase)IBA 01/2021 - 05/2005
7	JNK Mitogen-Activated Protein KinasesIBA 01/2022 - 12/2003
7	Insulin (Novolin)FDA Link 03/2016 - 04/2008
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2010 - 08/2003
6	Mitogen-Activated Protein Kinase 8IBA 12/2021 - 09/2006
6	Protein Isoforms (Isoforms)IBA 02/2016 - 12/2003
5	Mitogen-Activated Protein KinasesIBA 01/2022 - 02/2008
5	Interleukin-6 (Interleukin 6)IBA 11/2020 - 06/2005
5	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 06/2020 - 06/2002
5	Transcription Factors (Transcription Factor)IBA 01/2020 - 06/2005
4	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 09/2011
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 06/2020 - 02/2006
3	NF-kappa B (NF-kB)IBA 06/2020 - 06/2005
3	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 11/2004
3	IntegrinsIBA 08/2016 - 07/2013
3	Glycogen Synthase Kinase 3 betaIBA 12/2008 - 10/2003
3	Caspase 3 (Caspase-3)IBA 04/2008 - 01/2003
2	URMC-099IBA 01/2021 - 01/2019
2	fibroblast growth factor 21IBA 12/2020 - 03/2016
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2020 - 04/2011
2	CholesterolIBA 01/2020 - 06/2005
2	pyrazolanthroneIBA 08/2016 - 10/2010
2	Pharmaceutical PreparationsIBA 04/2016 - 08/2003
2	Acetaminophen (Paracetamol)FDA LinkGeneric 04/2016 - 07/2007
2	AndrogensIBA 01/2016 - 07/2012
2	Amyloid (Amyloid Fibrils)IBA 08/2015 - 11/2011
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2015 - 10/2012
2	MitogensIBA 06/2014 - 03/2009
2	AntigensIBA 12/2011 - 03/2007
2	AnisomycinIBA 10/2010 - 04/2010
2	beta CateninIBA 12/2008 - 10/2003
2	LipopolysaccharidesIBA 02/2008 - 07/2003
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 07/2007 - 09/2002
2	MAP Kinase Kinase 3IBA 06/2007 - 04/2006
2	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 05/2006 - 11/2004
2	SB 203580IBA 10/2005 - 08/2003
2	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2005 - 12/2004
2	Kainic Acid (Kainate)IBA 01/2005 - 11/2004
2	Heme Oxygenase-1IBA 09/2003 - 07/2003
2	Carbon MonoxideIBA 06/2003 - 01/2003
1	TRPP Cation ChannelsIBA 01/2022
1	Thioacetamide (Thioacetamid)IBA 12/2021
1	TunicamycinIBA 12/2021
1	Inositol (Myoinositol)IBA 12/2021
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 12/2021
1	4- (9- (tetrahydrofuran- 3- yl))- 8- (2,4,6- trifluorophenylamino)- 9H- purin- 2- ylaminocyclohexan- 1- olIBA 01/2021
1	Soluble Guanylyl CyclaseIBA 01/2021
1	Therapeutic UsesIBA 01/2021

Therapy/Procedure

6	Therapeutics 01/2016 - 05/2003
2	Radiotherapy 08/2016 - 06/2008
2	Injections 04/2016 - 04/2008
2	Ligation 01/2016 - 07/2014